AnywhereUSB/5 group setting inactive

There is no way to assign ports to different groups,group assignment tabs are inactive

It kind of depends which version of the AWUSB-5 you have. One model supports multi-host connections (and therefore Groups), the other does not.

Please see this section of the User Guide:
https://www.digi.com/resources/documentation/DigiDocs/90001085/default.htm#tasks/t_multihost_connections.htm