Cannot get code to run on processor in run and/or debug mode

I just loaded Dynamic C 10.64 and Rabbit RIO software and tried the basics of all programs, Demo1.C, to run on both RCM4210 and RCM4110. It Compiles. Compiles to Target, and when hitting RUN it acts like it is downloading then quits and closes connection.

Anyone with any idea why?

What operating system are you using? I suggest that you re-install Dynamic C. If you are using Windows 7, 64 bit version, you need to have your hardware attached while installing, otherwise Windows will use its own drivers for the USB programming cable.