Limitations? I think it’s a matter of getting the settings right because I can reach the configuration web page of the WR21 using a port forward on a Mikrotik router after the WR21 connects to the VPN server using PPTP.
Maybe it’s the default gateway? On another setup where in place of a WR21 I’ve used a USR-G806 I can reach the devices behind the 4G router just fine.
You need to add a Static Route :
Configuration - Network > IP Routing/Forwarding > IP Routing
Your server’s VPN as the gateway and 0.0.0.0 as the destination, make the Port Forwarding on both ends and that’s all.