FT232BM

Hi All,
I am trying to implement serial to USB & vice versa communication using FT232BM. Can you please guide me whether I have to use all handshaking signals or only RTS & CTS are sufficient for communication? & if these two signals are sufficient then what we have to do with other handshaking signals(ie. DTR, DCD etc.) Is there any good material which I can refer?

Thank you,
Rashmi.