What is the new card replacement for AccelePort Xem P/N: (1P)50000493-05 S/N: W84660376 ?

USB Devices
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Looks like the AccelePort XEM were a last time to buy on May 30th from Digi

I would look more at the PortServer TS products to replace those units since serial cards are not really used that much any more.

PortServer TS:

http://www.digi.com/products/serialservers/portservertsfamily/