Mesh Networking, Address Masks - Please explain

I am having a hard time understanding these concepts. Can You explain these for me?

I have a large network of thirty radios. Seven are base stations. All these will be in range of other base stations. What is the best addressing method. It looks like Source & Destination address enabled is the best. But what if you don’t know the number of radios on each base station. Then you have to wait until your in the field to decide which base station gets which remote. What a mess if you don’t pre-program the addresses. Is it better to set the hopping channel different on every base station?