RealPort drivers BSoD'ing Windows 7

Using RP x64 4.7.410.0 to connect to Digi Connect ES. On multiple PCs (Windows 7), driver has blue screened Windows, sometimes immediately after a connection, sometimes after many minutes of data transfer.

It’s not uncommon for anti-virus software to conflict with drivers and result in BSOD’s. Are these PCs running any anti-virus software?